Biography

Born:	December 30, 1971
Education:	2002 Ph.D. (Faculty of Sciences, Charles University) 1997 RNDr (Faculty of Sciences, Charles University) 1996 M.Sc. (Faculty of Sciences, Charles University)

Research Experience

2015-present	Group leader. Laboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague/BIOCEV.
2012-present	Project leader. Physiology and Pathophysiology of Digestive Epithelia, Functional Genomics Program, BIOCEV
2011-2014	Research Associate. Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague.
2003-2010	Assistant Professor/Research Associate. Department of Molecular Cell Biology, Max F. Perutz Laboratories, University of Vienna, Wien.
2002-2003	Assistant Professor. Faculty of Science, Deparment of Physiology and Developmental Biology, Charles University, Prague.

Professional Affiliations

Czech Physiological Society American Society for Cell Biology

Selected Publications

• Song J.-G., Kostan J., Drepper F., Knapp B., de Almeida Ribeiro Jr E., Konarev P.V., Grishkovskaya I., Wiche G., Gregor M.*, Svergun D.I., Warscheid B., Djinović-Carugo K.: Structural insights into Ca2+/calmodulin regulation of plectin 1a - integrin β4 interaction in hemidesmosomes. Structure, [Accepted], 2015.
• Gregor M.*, Osmanagic-Myers S.*, Burgstaller G., Wolfram M., Fischer I., Walko G., Resch G.P., Jörgl A., Herrmann H., Wiche G.: Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J., 28:715-29, 2014.
• Buryova H., Chalupsky K., Zbodakova O., Kanchev I., Jirouskova M., Gregor M., Sedlacek R.: Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity. BMC Gastroenterol., 13:155, 2013.
• Jirouskova M., Zbodakova O., Gregor M., Chalupsky K., Sarnova L., Hajduch M., Ehrmann J., Jirkovska M., Sedlacek R.: Hepatoprotective Effect of MMP-19 Deficiency in a Mouse Model of Chronic Liver Fibrosis. PLoS One, 7: e46271, 2012.
• Burgstaller G.*, Gregor M.*, Winter L., Wiche G.: Keeping the vimentin network under control: cell–matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol. Biol. Cell, 21: 3362–3375, 2010.
• Kostan J., Gregor M., Walko G., Wiche G.: Plectin isoform-dependent regulation of keratin–integrin α6β4 anchorage via Ca2+/calmodulin. J. Biol. Chem., 284: 18525-18536, 2009.
• Na S., Chowdhury F., Tay B., Ouyang M., Gregor M., Wang Y., Wiche G., Wang N.: Plectin contributes to mechanical properties of living cells. Am. J. Physiol. Cell Physiol., 296: C868-C877, 2009.
• Spurny R.*, Gregor M.*, Castañón M.J., Wiche G.: Plectin deficiency affects precursor formation and dynamics of vimentin networks. Exp. Cell Res. 314: 3570-3580, 2008.
• Osmanagic-Myers S.*, Gregor M.*, Walko G.*, Burgstaller G., Reipert S., Wiche G.: Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration. J. Cell Biol. 174: 557-68, 2006.
• Gregor M.*, Zeöld A.*, Oehler S., Andrä-Marobela K., Fuchs P., Weigel G., Hardie D.G., Wiche G.: Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibers. J. Cell Sci. 119: 1864-75, 2006.
• Tian R., Gregor M., Wiche G., Goldman J.E.: Plectin regulates the organization of GFAP in Alexander Disease. Am. J. Pathol. 168: 888-97, 2006.

 

*equally contributed authors